Scrubs star John C. McGinley wed his yoga teacher fiancee at their home in Malibu, California on Saturday.

McGinley, who plays bitter doctor Perry Cox in the hit sitcom, proposed to Nicole Kessler last summer after dating the blonde for just over two years.

Guests at the intimate family-and-friends nuptials included actor John Cusack, who hosted a rehearsal dinner for the bride and groom-to-be on Friday.

McGinley's nine-year-old son Max, who introduced the couple during a beach encounter, accompanied his new stepmother down the aisle.

It was the actor's second marriage; he was previously wed to Lauren Lambert.

It was a big weekend for McGinley - his new Ice Cube movie, Are We Done Yet?, opened in US cinemas on Friday.